Setup changed when opening project

I use the same axr mixer setup for all my cubase projects, for some reason when changing projects on cubase 11, the axr mixer loaded a setup where all inputs routed to the corresponding output. I use the control room, and my talkback mic (4) was routed to my speaker b (3-4). Blew my ears and ns10 tweeters.

Subsequently I opened several projects and haven’t been able to repeat this. Any idea why this happened?