Sound configuration for an Old Cubase LE.

I like to edit with my trusty old LE program that I got about 6-7 years ago with a basic Audio Interface. I’ve just replaced the interface with an M-Audio fast track interface but I am finding a conflict somewhere in my audio setup. To make matters worse I’m using a Windows Vista Operating System. And a Focusrite VRM box for different speaker configurations on playback. The setup was automatic, the VRM is playing back from everything but Cubase LE…iTunes, cd…, in fact I am receiving no audio when projects are played back from my CUbase system.

I believe the conflict is somewhere between the FOcusrite and the ASIO but can’t seem to fix it… And even worse I’m basically a musician and not a computer tech guy. Can anyone help…?