Strange popping/distortion when tracking

Hey guys, first time posting here. I’ve been using Cubase for almost a year now, and recently been encountering a problem with some sort of distortion/popping. I have a Saffire Pro 40, running my guitar DI from a Countryman direct box straight into the interface. The issue is sorta rare and it comes and goes, but it really interrupts my tracking sessions. I’ve attached screenshots of what it looks like, and here’s a clip of the popping at the end of a guitar note, running through an amp sim:
https://dl.dropboxusercontent.com/u/64301068/glitch.mp3
And here’s just the popping without an amp sim:
https://dl.dropboxusercontent.com/u/64301068/crackle.mp3

I really hope someone can help me figure this out. Thanks!
Screenshot 2016-02-22 16.41.31.png
Screenshot 2016-02-24 15.20.05.png