Trouble connecting new download of 10.5

I just installed V10.5 after not having used the software in over a year. I was previously recording with all of the same equipment (Steinberg UR22 mk11) but can’t get setup with this version. When I attempt to activate the Clean E-Guitar template I get this message:

Additionally, when I go into Studio Setup I get this screen showing output inactive:

And when I try to change the ASIO driver to the Yamaha Steinberg USB ASIO,
I receive this message twice and then the computer sits on the “preparing to install” message forever and I have to close the program:

I’ve been at this all day and don’t know where else to turn.

Hopefully one of you experts can point me in the right direction!

Thank you very much!

did you reboot after installing the driver?
is it the last available driver?