Unable to get sound from Cubase

I have recently had a problem whereby I have to reboot my Apple computer with the keyboard, audio interface and speakers switched in order to get sound out. Now, I cannot even do that.

I have discovered that the control room was inputted via output one and two but outputted by 3 and 4. Changing this and item seemed to work. Cubase 11 worked normally anyway. whereas I am using the latest v version of Cubase 12.