UR22 DSPMixFx shows 'No device found' in Windows 10

as the title follows,
I am using Windows operation system and a UR22 Steinberg hardware interface .But when I was opening DSPMixFx App,it showed 'No device found ‘.
I promise I had installed the drivers correctly following the manual (including shutting down PC and installing drivers without pluging the device )
cuz it showed options in sound setting, I believed that the hardware driver were installed exactly.
Even , the UR22 interface could be configured in my Cubase10 ,but when I closed the App’Cubase’ and tried to open Dsp, it could not find decive.
So, dear Team and kind strangers ,please how to solve this problem?
Thank you !
Best Regards.