Hello 
We connected the UR22mkii to MacBookPro with Mojave 10.4.2 and installed the Driver “Yamaha Steinberg USB Driver 1.10.2 of September 25, 2018”.
It just doesn’t connect to the Audio Midi Setup and on GarageBand you cannot control the Mic. We have installed the driver several times and it still wouldn’t work. 
We didn’t find a solution in the forums. What can we do to make it work?
Thanks for your help!