UR22c - loud piercing squeal sound

When ever I try to play my guitar (strat) through my ur22c , I get a loud piercing squeal sound .
This happens in cubase 11 artist when I use helix native plugin, and after failing miserably for weeks now I tried it with presonus studio 5 Pro…
Same problem . The sound is fine through the ur22c when played , it’s when I turn the nob closer to Daw the noise starts … really considering just giving up … I use a hp laptop 4gb 64bit and Windows 10 … please help :pray:

Is the loopback turned on?