UR22MKII USB Sync Drops

Hi there! I am having USB interruptions with my Yamaha Steinberg UR22MKII 2-Channel USB Interface.
It drops the connection for 1 second then it comes back. The issue happens with iTunes, and every other app that is using audio so it’s not isolated to one single app. It’s almost 1-2 drops per minute.
Also tried different cables, and different USB ports (not a USB-hub).

Any idea what could this be?

Thank you!

Driver is up-to-date?
A broken computer?
Can you try it with a different system?