I have just set up a new computer and am using Cubase 11. Everything was going fine until I noticed a loud hissing noise coming from the left monitor when I soloed the bass to finesse the Amplitude 5 bass sound. At first I thought it was an un licensed plugin. So tuned off all the plugins on that channel. I shut down all the plugins, but was still hearing it. So rebooted on Safe Mode disabling all the plugins. Sound still there and I noticed it was coming from the mono input from my RME Fireface UC. So I noticed that the sound was still coming from the left monitor. I switched the output leads on the RME and the noise transferred to the right speaker. So it was not the speaker.
Then I shut down Cubase and fired up an Amp Sim and using the same input channel from the RME played bass. No problem, no distortion or hiss. I then booted up Cubase 11 again and did a audio export of the soloed bass part. No hiss or distortion to be heard. I updated the drivers for the RME - no change. I downloaded Audacity and recorded a bass part with no issues.
I checked and double checked all the audio connections in Cubase, I made sure that the RNE Asio was selected and all the right outputs and inputs were checked. I phoned a Cubase using friend and neither of us could understand why it was only the stereo left that displayed this problem.
I am hoping some experienced user will tell me what I have done wrong. As it is I have reached the end of my tether with this after a long period of setting up a new computer.
Intel Core i9-10900KF CPU@3.70GHz - RME Fireface UC Soundcard