Hmmmmm…stand-by for a diagnosis of what Windows 10 Fall update has done to stop my MOTU Midi Express 128 Professional MIDI USB Interface from being recognised.
Update: I was using MOTU MIDI Installer v126.96.36.19983 (Release Date 2013-05-01) After the Creator Fall Windows update I found that all 8 MIDI in front-panel lights were permanently on. After a reboot, they had gone out (the green ‘Computer I/O’ light stayed on all the time), but Cubase couldn’t see the MIDI ports as being available.
So I uninstalled the MOTU drivers, rebooted and re-installed the same version, and all seems well again. Weird/annoying, but at least we don’t need to worry that the MOTU web-site only says these drivers work on Win7 and 8. They are working now on Windows 10 Pro (64-bit) version 1709 OS Build 16299.19 without any need for (re)configuration or manual tweaks.
Also, my Focusrite Liquid Saffire 56 (via Texas Instruments 1394 OHCI firewire adaptor) is also working fine with the new Windows version, with no need for re-installs, re-configuration or manual workarounds either.