Hi @musicullum,
indeed, when I tried creating a new project with version 2.2.83 (but I also tried with 2.2.85 with the same result), the issue, as you stated, doesn’t occur.
I think I understand that the issue occurs when (as happened with my test project) the routing, and specifically the sending in the mixer, was created with a previous VST Live 2 version, in my case, version 2.2.80.
Perhaps (but this is purely hypothetical) the issue I describe in this post is somehow related to what was reported in the post:
[3.0.1] Loss of Sends on certain channels - VST Live - Steinberg Forums
Looking forward to further feedback, as always, thanks for all your work. 