Right, got it sorted. Thank goodness for that. C14 duplicated the profile.
For anyone else that runs into this, here’s what worked.
First, run Cubase and go to Edit > Profile Manager, click on “Default” then click on “Activate Profile”.
Restart Cubase, go back to the Profile Manager to confirm the default profile loaded, it should have a check 
next to “Default”. Once confirmed, quit Cubase.
Now open up File Explorer and ensure hidden items are visible by going to View > Show > Hidden Items
Now navigate to the following directory;
C:\Users(YOUR USER NAME)\AppData\Roaming\Steinberg\Application Files
In this location, there will be folders for Cubase versions, inside each of these will be a Profile folder.
Open Cubase 13 > Profile folder and check if the profile you’re having issues with is there. If so, move it out of this folder to your desktop (for now). In this case “profile - Marcus 2024.srf”
Go back and open the Cubase 14 > Profile folder and delete the duplicated profile.
*(optional but did this anyway to ensure no problems) *
Run Cubase 14, open the profile manager and just check your original profile is not listed. Now close Cubase.
Now the profile you moved to the desktop, move it into the Cubase 14 folder mentioned above. Run, Cubase 14 activate your profile, and restart Cubase and it should now work.