Though unscientific, there seems to be little consensus, in this regard, so I’ll just share my experience on my system.
That said, Waves do have known issues with larger plugin counts that even Waves support will admit (as of this time of writing).
I’m having issues in large Cubase projects (10G+) with mainly Waves, iZotope and Softube.
In these same troubled sessions, plugins that are working (filling the void) are Slate Digital, Plugin Alliance, Sound Toys, U-He and Native Instruments.
This is just with a couple projects that are, admittedly, derivatives of each other, and on my particular system – though I have gone to great lengths to keep the system clean and it’s for DAW use only.
I don’t have an exhaustive list yet, but will update my other post once I do:
And, with any luck, Cubase 8.0.20 might improve this. It will be easy to test, I’ll know right away, as the crashes are highly repeatable.