Can't update my VST routing

I have a project that won’t allow me to change the plugin routing of my instruments in Play Mode. Most of the options in the Play menu on top are grayed out as well.

The transport button is sometimes grayed out too, even though the audio engine is active.

Welcome to the forum @sj2010.

Would you please choose from Dorico’s menu Help > Create Diagnostics Report and post the corresponding zip file here. Thanks