Sadly, I disable it in windows and in Cubase. I done it a while back.
Things may be better now - trouble is all my workspace presets are setup for the current resolution and scale so don’t going back to HiDPI modes as everything goes wonky.
There are settings within Cubase such as “Allow windows to be resized” which can fix such issues, i.e.:
Maybe try that? …but as the link suggests, some OpenGL plugins still don’t display correctly. I don’t own Omnisphere to have first hand experience, sorry.