Are you asking if Kontakt Player works with Cubase? If so, the answer is yes. Cubase is possibly the most commonly used DAW for Kontakt player. If you need help, you’ll probably have to provide more information. For example, are you asking how to use VST plugins in Cubase? If, on the other hand, your question is specific to Kontakt, you could contact NI, or ask in their forum. If your question is about Substance, you should contact Output.