My status:
Running Cubase 12 Pro. The 12.0.20 update did nothing for me 
Having overload spikes, even when at rest, with any combination of VSTs. When I turn off Asio Guard, I still get dropouts. Only difference with it off is that the performance meter doesn’t light up red, despite being audibly dropping.
Latencymon all green, no issues even after running for over 60 minutes. I even bought an AMD GPU to replace my nVidia GPU since Latencymon was showing high issues with their drivers.
I have disabled C-State, Simultaneous Multi-threading (SMT), implemented MSI fix for DPC HDAud.sys Latencymon spike, turned on Steinberg Audio Power. I have erased and installed Windows / the system more than once. No improvement.
My system:
CPU: AMD 5900x
RAM: 64GB Viper 3600Mhz
Motherboard: Vision D-P Gigabyte motherboard
GPU: AMD RX 6600-XT Gigabyte Eagle
Interface: PreSonus 26x32 Quantum Thunderbolt
SSD programs = 970 Evo
SSD sample libraries = 970 Evo & Gigabyte Auros
Suggestions welcome. I couldn’t post this on the bigger thread as it’s been closed soon after the 20.0.20 update (perhaps an idea could have been to wait a bit longer before closing it, to see how well the update performs for users)?