Does it crash on loading / opening, or does it load fine and instead crash while playing?
Runs the Play engine as stand-alone?
there’s a big problem with MR and UR users and EW Play which causes crashes, I see though that you’re not a MR or UR user which is interesting.
Even with last one (quite new) update of UR driver?
Btw: I have no problem with my MR816CSX on Mac OS X.
this is a well documented windows issue as Play has a memory overflow problem that impacts with the Cubase UR or MR extensions.