I’ve been working this problem for a while… still not happy. Here are the details.
Cubase 9.5.41 and Kontakt (up to date and multiprocessing is off) on Win10 64bit with RME AIO (updated) and NVIDIA GT1050ti
Intel i7 5820K (6 core, 12 threads). Memory tests are fine. Operating is on SSD for OS and SSD for samples.
Previously this system could run hundreds of channels of VSTs with many instances of Kontakt at ulta low latencies… no problem. Now just one instance of Kontakt playing a piano patch or a Spitfire sample, and the Real Time Performance monitor will clip constantly at any buffer setting. It’s completely unusable.
I have completed the Windows configurations, and even tried the Win10 dropouts suggestions (audioengine.properties) without benefit.
Latencymon shows no problems.
Where do I go from here?