Hi - this caught me out the other day too… Not at my machine, but something to check which I didn’t know about before… See here:-
Go to the header ‘Main’ - look at extreme right, just beyond the word ‘stereo’. There’s a button there to click that enables/disables the ControlRoom.
I thought I’d properly checked everywhere, making sure outputs were assigned/active and the CR was ‘enabled’; but turns out, somehow, this got disabled… Well, I stopped sweating after finding that teeny tiny little button (by accident.!), running the trauma in my mind of maybe reinstalling everything to fix this, etc, etc…
My machine is old (very old) but thankfully still getting work done. This year (finally) is upgrade year.! Goodness knows what would’ve got completely ‘upset’ at having a full reinstall thrown at it…
Anyway, worked for me… maybe it helps you too… 