Cubase timing goes out after system running for 30 minutes or so

Cubase
1

Cubase 14 Pro with latest update.
Windows 10.
32GB RAM.
Loads of disk space.
MOTU828ES with ADAT to two 8PRE interfaces.

If I have a session running for a moderate period of time Cubase stops being in time with itself. The symptom is demonstrated by:

  • midi piano notes not firing off at the right times
  • keyboard presses of midi controllers being sounded with latency
  • audio clock to other devices (DIN SYNC, control voltage) being behind the grid

Resolution

  • Restarting Cubase doesn’t help
  • Restaring MOTU 828ES fixes issue
  • Restarting PC fixes issue

I have no idea what to to about this and need some help to resolve.

2

could be related to midi clock system timer issues. In the midi system setup you have 3 options for midi. No tick, which uses windows midi, tick directmusic, which uses directmusic (surprising) and windows RT midi. Try changing these options one by one.
I checked and you have evn more tick boxes then I remembered. All might cure it. It will be trial and error. Also you can post here how it is set now and I might have a clue. My settings and they are working are only use device direct music ticked. Rest unticked.