Device dropping connection intermittently causing dropouts

If you came here to point me to I have already been through those steps multiple times using the following ports/devices.

Inateck USB3 expansion card
ASmedia 3.1 Hub
Intel USB Hub

Tried these with a variety of cables and configurations. Contacting support tomorrow, but wondered if anyone else encountered these issues and found a solution? My power settings are all configured in both the device manager as well as power settings relating to Windows 10 performance.

Computer Specs:
Board Asus Z370-E
Processor Intel(R) Coreā„¢ i7-8700 CPU @ 3.20GHz, 3201 Mhz, 6 Core(s), 6 Logical Processor(s)
Installed Physical Memory (RAM) 32.0 GB
Hardrive 1tb Intel NVME Drive
OS Name: Microsoft Windows 10 Pro
Version 10.0.18362 Build 18362
BIOS Version/Date American Megatrends Inc. 2401, 7/12/2019