Device is being used by another application

Just installed the UR242 on a new Windows 10 box. I have installed the latest firmware and driver.

I can see the device in Control Panel -> Hardware and Sound -> Sound. If I right click it and choose Test I will hear a tone in the left ear and then right ear of my headphones. Then I receive the following message:

The device is being used by another application. Please close any devices that are playing audio to this device and then try again.

There are no other applications running. I have disconnected Wi-Fi, and verified nothing is open in the Task Manager.

I cannot get any sound from the UR242 (iTunes, DAW, etc) at all.

I have uninstalled and re-installed the driver 3 times.

Any help will be greatly appreciated.