Cubase Nuendo do not yet support dynamic plugin delay compensation like Protools and Reaper do.
This complicates the use of plugins that host other plugins. Currently PDC is only compensated on plugin power on.
If steinberg supported more inserts and complex plugin routing (multi parallel routing without the need for many mixer channels) plugins like bluecat patchworks would not be needed. As it stands they are needed and the lack of dynamic PDC is a hindrance to their use.
Blue cat audio says this about their Patchworks plugin.
"Latency compensation works in cubase (as well as inside our plug-ins: parallel chains are compensated), but you may have to disable/enable the plug-in to have cubase take changes into account (it is not able to dynamically detect latency changes when you insert a new plug-in inside ours).
Unfortunately Steinberg’s internal plug-ins such as hardware insertes cannot be hosted (it’s not actually a plug-in that can be used by third parties). But there are probably other VST solutions to to this… If not we may just build one .
Yes, the activate/deactivate thing in Cubase is not convenient. Fortunately, there are other hosts out there that can handle dynamic latency without any problem (Pro Tools or Reaper for example, to name a few). Also, you have to do this only when inserting a new plug-in that changes latency. Once it’s in there, it will just work.
VST MIDI output is not yet supported, so an arpeggiator in the chain will not work for now."