If you can, go with single coil pickups, a lot of short delay with the feedback set fairly high, then going into a plate (or pan reverb) set to a long decay time. A Hall verb would probably get the job done as well. Fender blackface amp would probably be the best choice.
If you’re doing it entirely in Cubase, I’d say to load the VST Amp Rack with the Clean Compressor preset. Add a delay stomp pedal there and set the delay time fairly short (around 100ms), Feedback 50, mix 50. For even more cavernous sound, add another stop with the tape delay, but set it around 300ms, 50, 50. Go to the post effects and turn the Hall reverb mix up. For more drive, consider switching to the Deluxe Amp (or personally I’d say duplicate the track, set one Blackface, set one to Deluxe).
Processing-wise in Cubase, drop out a lot of the low end (in the EQ shelf it out), add a tube type compressor (personally I use the Nomad Blue Tubes, but I think you could get a very similar sound with the Tube Compressor or the Vintage Compressor directly in Cubase), a little brickwall limiter at the end just to make sure things don’t go over and you’re set. Hope this helps!