Look at the panner in the mixconsole. You may have chosen the “Bypass Panner” function. Hover your mouse over the panner and on the left you will see button that looks like a clock. Clicking on that button toggles the bypass function.
Based on your first screenshot of the CB Mixconsole, it looks like Audio Tracks 1 & 2 will pan as you have them adjusted. The stereo out channel (set to center) does show some panning. So, as mentioned by some above, I would think that something in the RME TotalMix FX software is probably not set correctly and is causing the output to be sent to both sides of the stereo output. That’s where I would concentrate my efforts. Sorry that I am not familiar with that software to assist with troubleshooting it.
As far as I can tell from your screen grab (sorry it’s some years since I used RME TotalMix) the AN1 and AN2 Software Playback channels are split (I’ve only ever seen them as one joint stereo channel). Looks like you’ll need to pan them hard left and right for any of your panning in Cubase to work.
Russ