is UR22 driver is tested on Windows 10?

Yes. Today I could confirm UR22 ASIO drivers are ok with Windows 10. As for sample rating being lowered down to 48 KHz, it seems the virtual instrument software is trying to match the interface sample rate to the loaded sample set. As I had not previous experience with ASIO drivers, except for ASIO4ALL, I thought it would have something to do with Windows 10 incompability. I will wait patiently for the certified WDM drivers.