LE4 crashes on startup

I have installed an OEM version of LE4 on a Pentium 4 PC with 2 GB of memory. Install went as expected, no issues, however, when I try to open the app I get a Windows error when it is initializing the MIDI. Any ideas as to what may be causing this and any possible solutions? I would like to get this up and running on my PC.
Thanks in advanced for any help or suggestions.

What MIDI compatible hardware/soundcards or in-memory utilities are installed on your PC? What OS? XP?