Loupedeck an Cubase 11 no connection after restart

Hi there,
crazy! after new installation of loupdek, cubase (11.5.) can be controlled with loupedeck ct.
But after restart of the PC there is no connection anymore. BUT Windows still works with loupedeck so it must be a Cubase thing.
So what can be the trouble? Even the guys of loupedeck have no explanation. I Followed every step, they proposed.

Is here someone who could help me?

Has there anybody an idea?