Martin
Yes I run a MOTU 128 for standard midi Din. Also I have a Akai LPD8, Faderport & Moog Subsequent 37 all connected via USB.
When I first experienced the crashes I disabled all of those and still the same issue.
The project (even a default template) would look like it was booting from the Hub but then after seemingly loading the tracks etc right at the end the whole program would just shut down.