This can be a strange one, based on what I’ve read from others. I use a pair of FHD (1920x1080) panels with only the integrated Intel graphics and have had no problems with HiDPI either on or off. Others report that C10 for them is almost unusable compared to C9. It seems to be mainly on Windows (which itself is still struggling with high resolution screens) and it may be related to specific graphics hardware and drivers.
The issues are also compounded by some plugins that can’t handle high resolutions.
In terms of high resolution graphics on Windows, be careful what you ask for. If you’re thinking of upgrading from a 28" FHD to a 28" UHD it may seem like a massive increase in screen “real estate”, but you’ll probably have to scale the UHD to 200% in order to be able to actually see anything, so in the end, the physical size will in fact remain the same, but you will have introduced lots of potential problems with applications and plugins while Microsoft and developers all struggle to get their heads around the marvellous hardware that we could only have dreamt about a few years ago.
(PS I have C10 but still on C9.5.50 for daily use because of the mess they’ve made of the floating Transport Panel)