Just discovered this since starting to use external synths/mixers and bouncing alot of audio in cubase (before that it was just offlining a laden project … Not so say I didnt have those problems in offline - but definitely have em in realtime bouncing of external synths.
It was also more noticeable to me at high bpm projects.
I currently am getting drifts of 3 and 6 samples @145 BPM, 48K (cubase 5.52, winXP)
My cubase is not synced to my (Sonic Core) card. I am currently studying the problem and will try external sync (never used it)