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Turn computer on.
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Start Cubase and open a project.
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Midi not being routed to correct outputs on hardware midi interface (Cakewalk UM3G, 3x connected via usb)
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Close down Cubase and then open up Cubase, then open up same project.
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Midi routings now correct.
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Midi routings stay correct until next computer restart.
Same in Cubase 5.5 and 5.5.3