Midi to Audio

1 L/R stereo input 3/4 inch jack
1 headphone output
2 Mono Mic inputs - Phantom on one, no phantom on other
Is the issue of balanced and unbalanced why I am getting USB buzzing? It’s not a grounding problem, it only happens when I have my USB plugged in on the fantom, if I do not have it plugged in the buzzing is gone.
if latency is lower with PCI-e then PCIE sound card with 1 Stereo L/R input, otherwise USB