So tripple post here, but I had an “heureka” moment yesterday regarding this issue and I wanted to share for others who are experiencing similar things.
So the problem is not “only” Waves, but it is part of the problem, mainly because of the Licenses on a USB stick.
Nuendo also momentarily froze when loading Trackpresets, opening the pool, and doing similar things where it had to use or read somekind of file somewhere in the system outside of the Nuendo folders. So that got me thinking and kamil certainly pointed in the right direction!
The problem was not the USB stick messing with something, but it actually was something blocking Nuendo accessing the filesystem.
Actually I had 3 Networkdrives connected to the other studios to be able to easily sync up keycommands and configs throughout the rooms. When all the rooms were turned on I did not have any problems, but it came back the next morning when only this one studio was running. So Nuendo is actually checking the networkdrives while checking for Waves Licenses or while opening a preset etc. but can’t be reached and the system freezes until some sort of timeout by the OS, that the drive is not reachable.
The solution was to remove the networkdrives which are potentionally “not connected” at any given time and I solved the syncing in a different way.
I am so happy to have solved this problem and the system now runs smooth an fast.
Thanks again kamil to have pointed me in the right direction.