I don’t know if you resolved this, but I have some clues from my system that may help.
Changing from Nvidia 1080 to radeon pro w5700 seemed to help, but only of a while - problems with graphics and crashes were more frequent overtime.
I spent last week searching for solution changing configuration, updating and reversing drivers and so on.
my conslusion is that some OpenGL plugins (for example rx 8 declicker) crash nuendo if I run Nuendo in graphic adapter “performance mode”. the plugin gui doesn’t have to be visible to crash - crashes happen even if I have rx 8 declicker in DOP with DOP window closed.
when I switch graphic adapter to optimal quality plugins graphics works well, but - I have stuttering video if video is full screen.
So as a workaround I work with graphic adapter “opimal quality” mode with windowed video - that stopped rx 8 and other to crash.
Newest radeon pro driver don’t have quick switch between graphic modes, so I rolled back to 20Q4 which is a last that have it.
I’m not sure if this could be the case in other systems, but it works for me for now.
my configuration is
i9 9900k, asus z390WS, 32GB ram, radeon pro w5700, nuage master, nuage fader x2, rme hdspe madifx, win10 21H1, N11.02