had similar problems with Nuendo 8.3 on a W10, i9 machine combined with Nuage and with exactly the AMD Firepro W5100 in 2019. In my case Nuendo crashed occasionaly without exact reasons, sometimes even without any action. Couldn’t solve the problem and returned the machine to my specialized reseller because there was no solution for the problem (it was brandnew). Since 8.3 Nuendo seems to be very picky regarding graphics cards or some mainboard-graphic cards-processor combinations… Perhaps you could change the graphics card - that was the only “solution” the steinberg support had. But it was weired because regarding to the specialized post pro studio reseller this configuration (except the processor type that was brandnew) worked at other clients.
Sorry that i can’t tell you a solution but i hope with more bug-reports steinberg will maintain their QA departement as there seems to be some essential gaps (I had also some weired bugs with Nuendo10.3 on macs - but luckily not as hard as the crash while working but often also problems with the graphics. Since the introduction of the new faster developement cycles there seems to be a growth of bugs also).
Hope you find a solution and get your system running reliable.