A few things before I get my New Years party hat on.
Refer to this link for general information on how to get going…
Specific to your setup:
You will need to pick the ASIO driver that came with your m-audio interface in the VST audio connection section.
You need to set the m-audio inputs and outputs (called busses) in the VST connections section (see the separate tabs for inputs and outputs).
You will not be able to use the m-audio for recording and the speakers connected to your PC for playback/monitoring. You need to connect a set of speakers to the m-audio outputs. Use the PC speakers (temporarily) for this purpose. If you can’t do that then connect a set of earphones to the front of the m-audio to monitor/hear things.
Hopefully the information in the link and the little information I provided will get you going for day one 2016 use.
Now… it’s party time. 
Good luck
HAPPY NEW YEAR!
Regards 