Each time I press save during playback and there is a track in the project where a long note over several bars triggers an instrument with an arp the arp stops to play until the next note starts. As I have to save constantly due to the many crashes in Cubase this is a very bad behavior.
Don’t want to look as a smart a**, but well… Saving during playback is something that I would never attempt to do, as several project files can be used in the process. How the system is supposed to react, summoned to read and write at the same time on the same file(s) ? 
I would expect instant added crashes doing this…
I think it would be better to look for your crashes culprit(s).