Strange thing,
Imported into profile manager my profile after clean instal of high sierra and nuendo. There were a default profile there too. So I selected my profile and click on activate. Restarted the app… and default is still selected. I’ve done this 5 times to no avail.
PS from first launch nuendo gave me an error that couldn’t find padshop vst 113… I had to point to it… very strange. Never saw this again. fixed. but WHY? Clean install!