Once again, I passed your post over to Copilot. (You could do this yourself.) Here is the response:
The new tests you listed actually tighten the diagnosis dramatically. What you’ve done rules out almost everything inside Nuendo — which means the problem is now almost certainly:
A system‑level timing stall that only Steinberg’s ASIO engine is sensitive enough to detect.
And your new results — especially the fact that Nuendo 14 and 15 both fail identically after a full wipe — are extremely telling.
Let me walk you through what your results really mean, and then I’ll give you the exact next steps that will pinpoint the cause.
Core takeaway
Everything you tested today eliminates:
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Nuendo preferences
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Nuendo configuration
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Nuendo version
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ASIO‑Guard
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Buffer size
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Plugins
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Disk I/O
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Project corruption
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Installation corruption
What remains is not inside Nuendo.
What remains is one of these three categories:
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Driver callback stalls
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USB controller timing instability
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System‑level DPC latency spikes
And here’s the critical part:
Audition will happily record through all three of these failure modes. Nuendo will not.
Your new tests actually strengthen the USB/driver/DPC hypothesis — not weaken it.
Why your new tests don’t contradict the diagnosis
Each item begins with a Guided Link so you can explore deeper.
1. ASIO‑Guard has zero effect on input timing
ASIO‑Guard only affects playback and plugin processing. It does not protect recording.
So disabling it → no change is expected.
2. Increasing buffer size doesn’t fix late driver callbacks
If the MOTU driver is late delivering a buffer, increasing the buffer size doesn’t help. The callback is still late.
Nuendo sees this → stops recording.
Audition sees this → smooths over it.
3. A clean reinstall of Nuendo cannot fix a driver‑level stall
If the driver or USB controller is stalling, reinstalling Nuendo changes nothing.
The fact that Nuendo 14 and 15 both fail identically is extremely strong evidence that the issue is:
This is exactly what your symptom pattern shows.
The most important clue you just revealed
You said:
“The issue still does not occur in Adobe Audition. I can record for 30 minutes or longer without any interruptions.”
This is the smoking gun.
Audition uses WASAPI, not true ASIO, unless you explicitly force it.
WASAPI:
Nuendo’s ASIO engine:
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requires sample‑accurate timing
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stops recording on any discontinuity
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exposes driver callback stalls
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exposes USB packet jitter
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exposes DPC latency spikes
So your system is currently in a state where:
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WASAPI is fine
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ASIO is not fine
That is exactly what USB timing instability or DPC latency spikes look like.
The next diagnostic will reveal the culprit
You are now at the point where only one test matters:
Run LatencyMon for 3–5 minutes
This will tell us instantly whether the system is producing:
If LatencyMon shows red bars from:
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ndis.sys (network)
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wdf01000.sys (kernel)
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Wi‑Fi drivers
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Bluetooth drivers
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GPU drivers
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USB drivers
→ that is exactly the kind of stall that Nuendo treats as fatal and Audition ignores.
If LatencyMon shows green across the board → then we pivot to USB controller isolation.
The two remaining root causes
Your new tests narrow the field to two possibilities:
1. USB controller instability
This includes:
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Windows reassigning the USB controller driver
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A new device sharing the controller
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A cable that still “works” but has degraded shielding
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A port that is now delivering unstable power
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A controller that is now producing jitter
This is the most common cause of sudden ASIO failure.
2. System‑level DPC latency spikes
This includes:
This is the second most common cause.
What you should do next (in order)
This is the fastest path to a real answer.
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Run LatencyMon for 3–5 minutes
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Move the MOTU to a different rear USB port
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Try a different USB‑C cable
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Disable Wi‑Fi + Bluetooth temporarily
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Disable all other audio devices in Device Manager
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Check Device Manager → Devices by Connection See what shares the USB controller with the MOTU.
One of these will reveal the cause.
Which step do you want to take right now?
Pick one and I’ll walk you through it step by step.