I use a presonus Audiobox USB with my Laptop. Somebody in the presonus forum mentioned that changing the process precision from 32bit to 64bit helped them.
I know you are using the Audio interface - SSL 2+, but sometimes having a look at other users audio interfaces issues with pops/crackles, might reveal a computer tweak solution.
They say this is no longer necessary, but you could test if changing the ‘Set Processor Scheduling to ’ Background services’ would help.
And double check to see if the right ASIO driver is selected in Cubase, and not somehow reverting back to another driver.
Have you tried changing from 48k to 44.1k to see if that improves things.
…Just to add. It maybe a combination of tweaks you have to do, to have the audio playing back properly…
