Question on Realtime Performance/Latency with Rosetta 2 on a Mac

Hey there,
I’m planing to buy a new Macbook Pro but since I use a lot of Native Instruments stuff I cannot use Cubase in native mode yet. So I would have to use it via Rosetta 2. Since I heavily rely on low latency for what I’m doing I wanted to ask if Rosetta 2 has any effect on latency. If that would be the case I still had to wait buying it. I am using a Focusrite Scarlett 4i4 3rd Gen interface.

Another question: Does the Focusrite driver also have to run via Rosetta when Cubase does or can I let the Focusrite run native while Cubase runs via Rosetta?

Kind regards,
Eric