I had random crashes for over a year with Nuendo 10 and now 11.
it wasn’t very frequent, but annoying as hell becasue Nuendo was closing without any warning and dump file.
I tought it was related to some plugin, but as I found out - it was caused by CPU temperature.
I use i9 9900k and it had not sufficient enough cooling - and as soon as CPU hit 90 celcius it caused Nuendo crashes.
You can measure your CPU temperature realitme with for example CPUID HWmonitor.
hope this helps someone else.