With maya44 ex I can reach the maximum allowed by the sound card, 48 samples, 24 bit 48k, 2 ms roundtrip, with about 20 audio tracks, halion groove agent 3 or 4 vst amp rack and various equalizations, use of the cpu at about 1/8, win 10 is optimized by following the steinberg and focusrite suggestions for more on the internet.
With the scarlett 2i2 2gen usb 2 I can work at 32 samples with 4ms of roundtrip, cpu at 1/4.
I don’t have big needs, I use cubase since Atari at amateur level.
As a guitarist I use vst amp rack, so I usually look for the lowest workable latency.
Midi keyboards are connected via USB port without delay problems.
The maya preamps like the drivers are not the best but for that price there is nothing better.
With win 95/98/xp I used echo Darla 24, another level of sound card.
Probably in a few months I’ll move on to something more professional. I hope RME, and then I’ll tell you.
Bye.