I have this problems from couple of months and I am in a dead end.
I am using Cubase Pro 9.5, up to date, Steinberg UR22mkII, Roland cables, laptop Lenovo ThinkPad T560 (i5 6300 U, 16Gb RAM, SSD),Windows 7.
This is the problem: while playing, everything is fine, but the sound drops out for couple of seconds and then goes on normally. Sometimes only the guitar sound disappear, the recorded sounds and drums play, sometimes all sounds gone. Everything is up to date, drivers, Cubase, plugins. Asio guiard disabled. Sometimes this happens also in mixing process, guitar or bass turned on.
Reinstalled Windows and all the programs and plugins, every update is installed and still this annoying drop out remains.
Please, if You have any ideas what to do, it would be awesome.