Sound periodically stops working

I’ll be working on a project and the sound will just stop working. I have to close out the project and then restart the project to get the sound working again. This problem used to occur about once every hour or two of use. But lately in my latest project, in which I’ve recorded a lot of takes, the sound will drop out after about every 10 to 30 minutes or so of use. Any ideas what might be causing this?

Nuendo 7.1.40
RME Babyface
Windows 10
Intel Core i7 - 8700 3.2 GB