Depends on the buffersize you can/want to work in.
And why you need low latency, if you are recording guitar using amp modelling plugins then it is important.
Or using midi keyboard and VSTi playing them realtime.
If you are playing analog/digital synths and using real guitar amps and fx, it is kind of irrelevant, just use Direct Monitoring.
I have played hundreds of gigs live in the past and mostly with poor monitoring, so i’m conditioned to huge latency 20ms +
Around 7ms or below is my comfort zone, for playing midi keyboard/VSTi, but we are all different so find out where your comfort zone is.
And some numbers, I’m using a RME Raydat, Latency numbers in Cubase are:
All 44.1 khz
Buffer 32 IN 0,771ms OUT 1,519ms
Buffer 64 IN 1,497ms OUT 2,245ms
Buffer 128 IN 2,948ms OUT 3,996ms
Buffer 256 IN 5,850ms OUT 6,599ms
Buffer 512 IN 11,655ms OUT 12,404ms
Those are good numbers, that of cause would be smaller at higher bit rates.
That makes it possible for me to play comfortable at 256 buffers, and leave enough breathing room for the CPU.