Trouble using Nuendo with an iFi iDSD or similar device?

Hi all,
I picked up one of these little guys:

And it works well with my iPad, OS 10.9, Pro Tools, Audiofinder, Audition, even Symbolic sound wrote a driver for the Kyma. But I can not for the life of me get it to work with Nuendo 6.5 or 7.

Nuendo sees the device, I set up the outputs, but no sound passes through the devices. The Nuendo channel and master meters show no activity at all when I try to use this device for sound out.

Has anyone had a similar issue, and if so did you find a workaround?

Thanks for in advance for suggestions.