OK… Absolutely bizarre coincidence it did indeed turn out to be.
I have a bunch of plugins bypassed on the Control Room inserts. I decided to try and actually turn them fully OFF to see if the problem went away, which it did, when I turned off the bx_solo plugin.
When I opened it, it was saying that I needed to activate it, and that there was a 14 day free trial… I checked their website; the plugin is still completely free. I signed in when prompted and now it seems to be working again.
So an ‘unlicensed’ (even though it’s completely free) instance of bx_solo that was BYPASSED on my Control Room inserts was causing terrible distortion, and it chose just to happen right after I installed the new CPU.
On the positive side, it forced me to just do 6 BIOS updates.
I wonder if the change of cpu meant the authorisation didn’t match your computer anymore. Cubase 12 has certain things that if changed will lose authorisation. Cpu at least doesn’t sound like one of them but this plugin does. Glad you found the problem.